Technology companies Oracle and AMD are expanding their long-time collaboration to help organizations scale their artificial intelligence (AI) operations using the next generation of cloud and chip technologies.
Oracle Cloud Infrastructure (OCI) will serve as the launch partner for AMD’s first publicly available AI supercluster powered by the AMD Instinct MI450 Series GPUs. The initial deployment will include 50,000 GPUs starting in the third quarter of 2026, with further expansion expected in 2027 and beyond.
The initiative extends the companies’ previous work, which began with the release of AMD Instinct MI300X-powered OCI shapes in 2024. OCI also plans to make available new compute instances using the AMD Instinct MI355X GPUs within its zettascale supercluster.
“Our customers are building some of the world’s most ambitious AI applications, and that requires robust, scalable, and high-performance infrastructure,” said Mahesh Thiagarajan, EVP of Oracle Cloud Infrastructure. “Through our decade-long collaboration with AMD, from EPYC to AMD Instinct accelerators, we’re continuing to deliver the best price-performance, open, secure, and scalable cloud foundation in partnership with AMD to meet customer needs for this next era of AI.”
As AI models continue to grow in size and complexity, demand for high-capacity, flexible compute systems is increasing. OCI’s planned superclusters will use AMD’s new “Helios” rack design, which combines AMD Instinct MI450 Series GPUs, AMD EPYC CPUs (codenamed “Venice”), and AMD Pensando networking (codenamed “Vulcano”). This architecture aims to support large-scale AI training and inference with greater efficiency and scalability.
“With our AMD Instinct GPUs, EPYC CPUs, and advanced AMD Pensando networking, Oracle customers gain powerful new capabilities for training, fine-tuning, and deploying the next generation of AI,” said said Forrest Norrod, executive vice president and general manager of the Data Center Solutions Business Group at AMD.
The AMD Instinct MI450 Series GPUs are designed for high-performance cloud deployment and support open-source tools used in AI and high-performance computing. Oracle has also made its OCI Compute with AMD Instinct MI355X GPUs generally available, offering customers more flexibility to train and run AI workloads at scale within the OCI Supercluster.